MovDisordV3, Main, Exploration, bibRecord, 002778

Low LDL cholesterol and increased risk of Parkinson's disease: Prospective results from Honolulu‐Asia Aging Study

Identifieur interne : 002778 ( Main/Exploration ); précédent : 002777; suivant : 002779

Low LDL cholesterol and increased risk of Parkinson's disease: Prospective results from Honolulu‐Asia Aging Study

Auteurs : Xuemei Huang [États-Unis] ; Robert D. Abbott [États-Unis, Japon] ; Helen Petrovitch [États-Unis] ; Richard B. Mailman [États-Unis] ; G. Webster Ross [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2008-05-15.

RBID : ISTEX:5C36103BECABD10CFC438E5F82F7CE84352A67BD

English descriptors

KwdEn :
- Aged, Aging (physiology), Apolipoprotein E2 (blood), Cholesterol, LDL (blood), Humans, LDL cholesterol, Male, Middle Aged, Parkinson Disease (blood), Parkinson Disease (epidemiology), Parkinson's disease, Prevalence, Prospective Studies, Questionnaires, Risk Factors, Smoking (epidemiology), apolipoprotein E, statin, prospective study.
MESH :
- chemical , blood : Apolipoprotein E2, Cholesterol, LDL.
- blood : Parkinson Disease.
- epidemiology : Parkinson Disease, Smoking.
- physiology : Aging.
- Aged, Humans, Male, Middle Aged, Prevalence, Prospective Studies, Questionnaires, Risk Factors.

Abstract

Low‐density lipoprotein cholesterol (LDL‐C) levels are suggested to be associated inversely with Parkinson's disease (PD). To test the hypothesis that LDL‐C levels may increase PD risk, we studied a prospective cohort of 3,233 men (Honolulu‐Asia Aging Study) for whom the LDL‐C from fasting lipid profiles was obtained during 1991 to 1993. The cohort was followed longitudinally until 2001 for incident Parkinson's cases. During follow‐up, 41 men developed PD (18.4/10,000 person‐years). Although the incidence of PD increased with decreasing LDL‐C in a dose‐dependent manner, the association was only significant for men aged 71 to 75 years. In the latter group, risk of PD declined from 38.5/10,000 person‐years in men with LDL‐C levels <80 mg/dl to less than 9/10,000 person‐years for concentrations that were ≥140 mg/dl. After adjustment for age, smoking, coffee intake, and other factors, the relative odds of PD for men at the 80th versus the 20th percentile of LDL‐C (135 vs. 85 mg/dl) was 0.4 (95% confidence interval: 0.2, 0.9). This prospective study supports the hypothesis that low LDL‐C is associated with an increased risk of PD. Although confirmation is required, the underlying mechanisms may be useful in understanding key aspects of PD. © 2008 Movement Disorder Society

Url:

https://api.istex.fr/document/5C36103BECABD10CFC438E5F82F7CE84352A67BD/fulltext/pdf

DOI: 10.1002/mds.22013

Affiliations:

Le document en format XML

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<author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
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<term>Humans</term>
<term>LDL cholesterol</term>
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<term>Parkinson's disease</term>
<term>Prevalence</term>
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<term>Questionnaires</term>
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<front><div type="abstract" xml:lang="en">Low‐density lipoprotein cholesterol (LDL‐C) levels are suggested to be associated inversely with Parkinson's disease (PD). To test the hypothesis that LDL‐C levels may increase PD risk, we studied a prospective cohort of 3,233 men (Honolulu‐Asia Aging Study) for whom the LDL‐C from fasting lipid profiles was obtained during 1991 to 1993. The cohort was followed longitudinally until 2001 for incident Parkinson's cases. During follow‐up, 41 men developed PD (18.4/10,000 person‐years). Although the incidence of PD increased with decreasing LDL‐C in a dose‐dependent manner, the association was only significant for men aged 71 to 75 years. In the latter group, risk of PD declined from 38.5/10,000 person‐years in men with LDL‐C levels <80 mg/dl to less than 9/10,000 person‐years for concentrations that were ≥140 mg/dl. After adjustment for age, smoking, coffee intake, and other factors, the relative odds of PD for men at the 80th versus the 20th percentile of LDL‐C (135 vs. 85 mg/dl) was 0.4 (95% confidence interval: 0.2, 0.9). This prospective study supports the hypothesis that low LDL‐C is associated with an increased risk of PD. Although confirmation is required, the underlying mechanisms may be useful in understanding key aspects of PD. © 2008 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

Low LDL cholesterol and increased risk of Parkinson's disease: Prospective results from Honolulu‐Asia Aging Study

Low LDL cholesterol and increased risk of Parkinson's disease: Prospective results from Honolulu‐Asia Aging Study

Source :

English descriptors

Abstract

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	Movement Disorders (revue)
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